Dr. Paul R. Reynolds

Dr. Paul R. Reynolds

Physiology & Developmental Biology

Email:paul_reynolds@byu.edu(Email Form)

 

3054 Life Sciences Building
Provo, UT 84602
(801) 422-1933

Associate Professor

Curriculum Vitae

Honors and Awards
  • American Physiological Society : American Physiology Minority Fellowship Award Mentor
  • American Society of Reproductive Immunology : CyPlex Systems American Society of Reproductive Immunology Grant
  • The American Physiological Society : The American Physiological Society Research Career Enhancement Award
  • International Union of Physiological Sciences Congress : International Travel Presentation Award
  • The American Physiological Society : Respiratory Section New Investigator Award
  • NIH: National Heart, Lung and Blood Institute : National Institutes of Health LRP Award: NHLBI Extramural Clinical Researcher
  • The American Physiological Society : The American Physiological Society Research Career Enhancement Award
  • Parker B. Francis Foundation : Parker B. Francis Fellowship in Pulmonary Research
Courses Taught

 

Fall 2014
  • NEURO 696R: Neuroscience Grad SeminarSection001
  • PDBIO 325: Tissue Biology (with lab)Section001, 002, 003, 004, 005
  • PDBIO 349R: PDBio Teaching SeminarSection013, 025
  • PDBIO 484: Human EmbryologySection001
  • PDBIO 494R: Undergraduate ResearchSection014
  • PDBIO 495R: Adv Undgraduate ResearchSection013
  • PDBIO 550R: Advanced TopicsSection014
  • PDBIO 601: Cell & Molecular PhysiologySection001
  • PDBIO 649R: Laboratory ResearchSection011
  • PDBIO 696R: Graduate SeminarSection001
  • PDBIO 699R: Master's ThesisSection013
  • PDBIO 799R: DissertationSection009
Summer 2014
  • PDBIO 494R: Undergraduate ResearchSection034
  • PDBIO 649R: Laboratory ResearchSection031
Spring 2014
  • PDBIO 494R: Undergraduate ResearchSection013
  • PDBIO 649R: Laboratory ResearchSection012
  • PDBIO 650R: ApoptosisSection003
Winter 2014
  • NEURO 696R: Neuroscience Grad SeminarSection001
  • PDBIO 325: Tissue Biology (with lab)Section001, 002, 003, 004, 005
  • PDBIO 349R: PDBio Teaching SeminarSection013
  • PDBIO 494R: Undergraduate ResearchSection013
  • PDBIO 495R: Adv Undgraduate ResearchSection013
  • PDBIO 550R: Advanced TopicsSection017
  • PDBIO 649R: Laboratory ResearchSection013
  • PDBIO 650R: Selected Topics in PDBio/NeuroSection002
  • PDBIO 689R: Practicum LfSci Tchg or ResrchSection004
  • PDBIO 696R: Graduate SeminarSection001
  • PDBIO 699R: Master's ThesisSection013
  • PDBIO 799R: DissertationSection008

 

Selected Publications

Journal Articles

Tippetts TS, Winden DR, Swensen AC, Nelson MB, Thatcher MO, Saito RR, Condie TB, Simmons KJ, Judd AM, Reynolds PR, et al. Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration. BMC Cardiovascular Disorders. 2014 Nov;14(1):165. 

Thatcher MO, Tippetts TS, Nelson MB, Swensen AC, Winden DR, Hansen ME, Anderson MC, Johnson IE, Porter JP, Reynolds PR, et al. Ceramides mediate cigarette smoke-induced metabolic disruption in mice. American Journal of Physiology - Endocrinology and Metabolism. 2014 Nov;307:E919-E927. 

Winden DR, Barton DB, Betteridge BC, Bodine JS, Jones CM, Rogers GD, Chavarria M, Wright AJ, Jergensen Zr, Jimenez FR, et al. Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation. Respir Res. 2014 Oct;15(1):129. 

Bodine Bg, Bennion BG, Leatham e, Jimenez FR, Wright AJ, Jergensen ZR, Erickson CJ, Jones CM, Johnson JP, Knapp SM, et al. Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation. Respir Res. 2014 Oct;15(1):133. 

Wood TT, Winden DR, Marlor DR, Wright AJ, Jones CM, Chavarria M, Rogers GD, Reynolds PR. Acute secondhand smoke-induced pulmonary inflammation is diminished in RAGE knock out mice. AJP: Lung Cell Mol Physiol. 2014 Sep;307(10):E919-27. 

Jimenez FR, Lewis BL, Belgique ST, Wood TT, Reynolds PR. Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2. Respiratory Research. 2014 Jun;15(1):70. 

Barton DB, Betteridge BC, Earley TD, Curtis CS, Robinson AB, Reynolds PR. Primary alveolar macrophages exposed to diesel particulate matter increase RAGE expression and activate RAGE signaling. Cell Tissue Research. 2014 Jan:EPub ahead of print. 

Winden DR, Ferguson NT, Bodine BG, Bukey BR, Geyer AJ, Wright AJ, Jergensen ZR, Robinson AB, Stogsdill JA, Reynolds PR. Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation. Respiratory Research. 2013 Oct;14(1):108. 

Stogsdill MP, Stogsdill JA, Bodine BG, Fredrickson AC, Sefcik TL, Wood TA, Kasteler SS, Reynolds PR. Conditional RAGE over expression in the adult murine lung causes airspace enlargement and induces inflammation. Am J Resp Cell Mol Biol. 2013 Oct;49(1):128-134. 

Larkin DJ, Kartchner JZ, Doxey AS, Hollis WR, Rees JL, Wilhelm SK, Draper CS, Peterson DM, Jackson GG, Ingersoll C, et al. Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-Products (RAGE). Frontiers in Integ Physiol. 2013 Oct;4(1):121. 

Ricks ML, Farrell JT, Falk DJ, Holt DW, Rees M, Carr J, Williams T, Nichols BA, Bridgewater LC, Reynolds PR, et al. Osteoarthritis in Temporomandibular Joint of Col2a1 Mutant Mice. Archives of Oral Biology. 2013 Aug;58(9):1092-9. 

Winden DR, Ferguson NT, Bukey BR, Geyer AJ, Wright AJ, Jergensen ZR, Robinson AB, Stogsdill JA, Reynolds PR. Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation. Respiratory Research. 2013 Jul;14(1):108-115. 

Larkin DJ, Kartchner JZ, Doxey AS, Hollis WR, Rees JL, Wilhelm SK, Draper CS, Peterson DM, Jackson GG, Ingersoll C, et al. Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-products (RAGE). Frontiers in Physiology. 2013 May;4:121-128. 

Robinson AB, Stogsdill JA, Lewis JP, Wood TA, Reynolds PR. RAGE and tobacco smoke: Insights into modeling Chronic Obstructive Pulmonary Disease. Frontiers in Respiratory Physiology. 2012 Jul;3(301):1-11. 

Robinson AB, Dickson KD, Bennion BG, Reynolds PR. RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation. American Journal of Physiology: Lung Cell Molecular Physiology. 2012 Jul;303:L1192-1199. 

Stogsdill JA, Stogsdill MP, Porter JL, Hancock JM, Robinson AB, Reynolds PR. Embryonic over-expression of RAGE by alveolar epithelium induces an imbalance between proliferation and apoptosis. American Journal of Respiratory Cell and Molecular Biology. 2012 Jul;47(1):60-66. 

Reynolds PR, Stogsdill JA, Stogsdill MM, Heimann NB. Conditional Up-regulation of Receptors for Advanced glycation End-Products (RAGE) in Murine Alveolar Epithelium Causes Severe Lung Hypoplasia and Perninatal Lethality. American Journal of Respiratory Cell and Molecular Biology. 2011 Dec;45(6):1195-202. 

Bukey BR, Geyer AJ, Porter JL, Reynolds PR. Immunohistochemical detection and regulation of alpha 5 nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis. Respiratory Research. 2011 Jun;12(1):11 pages. 

Reynolds PR, Allison CH, Willnauer CP. TTF-1 Regulates Alpha 5 Nicotinic Acetylcholine Receptor (nAChR) Subunits in Proximal and Distal Lung Epithelium. Resp Research. 2010 Dec;11(175). 

Reynolds PR, Wasley KM, Allison CH. Diesel Particulate Matter Induces RAGE Expression in Pulmonary Epithelium and RAGE Signaling Influences NF-κB-Mediated Inflammation. Env Health Pers. 2010 Nov;119(3):332-336. 

Reynolds PR, Kasteler SD, Schmitt RE, Hoidal JR. RAGE Signals Through Ras During Tobacco Smoke-Induced Pulmonary Inflammation. Am J Resp Cell Mol Biol. 2010 Sep. 

Rao NV, Argyle B, Xu Z, Reynolds PR, Walenga JM, Prechel M, Prestwich GD, Hoidal JR, Kennedy TP. Low Anticoagulant Heparin Targets Multiple Sites in Inflammation, Suppresses Heparin-Induced Thrombocytopenia and Inhibits Interaction of RAGE with its Disparate Ligands. AJP: Lung Cell Mol Physiol. 2010 Jul;1(299):97-110. 

Reynolds PR, Schmitt RE, Kasteler SD, Sturrock A, Sanders K, Bierhaus A, Nawroth PP, Robert Paine JH. RAGE Targeting Protects Against Hyperoxia-Induced Lung Injury in Mice. Am J Resp Cell Mol Biol. 2009 Jun;5(42):545-551. 

Reynolds PR, Kasteler SD, Cosio MG, Sturrock A, Huecksteadt T, Hoidal JR. RAGE: Developmental Expression and Positive Feedback Regulation by Egr-1 During Cigarette Smoke Exposure in Pulmonary Epithelial Cells. American Journal of Physiology: Lung Cell and Molecular Biology. 2008 Apr;6:1094-101. 

Reynolds PR, Hoidal JR. Cigarette Smoke-Induced Egr-1 Upregulates Pro-Inflammatory Cytokines in Pulmonary Epithelial Cells. Am J Resp Cell Mol Biol. 2006;35:314-9. 

Mukherjee TP, Reynolds PR, Hoidal JR. Differential Effect of Estrogen Receptor Alpha and Beta Agonists on the Receptor for Advanced Glycation End Product Expression in Human Microvascular Endothelial Cells. Biochim Biophys Acta. 2005;1745:300-9. 

Reynolds PR, Hoidal JR. Temporal-Spatial Expression and Transcriptional Regulation of ?7 Nicotinic Acetylcholine Receptor (nAChR) by TTF-1 and Egr-1 During Murine Lung Development. J Biol Chem. 2005;280:32548-54. 

Reynolds PR, Mucenski ML, LeCras TD, Nichols WC, Whitsett. JA. Midkine (MK) induces myocardin during hypoxia and causes pulmonary vascular remodeling. J Biol Chem. 2004;279:37124-32. 

Reynolds PR, Schaalje GB, Seegmiller RE. Combination Therapy with Folic Acid and Methionine in the Prevention of Retinoic Acid-Induced Cleft Palate in Mice. Birth Defects Research. 2003;67:168-173. 

Reynolds PR, Mucenski ML, Whitsett JA. Thyroid Transcription Factor (TTF)-1 Regulates the expression of Midkine (MK) During Lung Morphogenesis. Dev Dyn. 2003;227:227-237. 

Hansen JM, Reynolds PR, Booth GW, Schaalje GB, Seegmiller RE. Developmental Toxicity of Carbon Black Oil in Mice. Teratology. 2000 Jul;62:227-232. 

Abstract

Tippetts T, Winden DR, Wagner M, Condie T, Reynolds PR, Bikman BT. Ceramide is necessary for cigarette smoke-induced reduced heart mitochondrial function. Diabetes. 2014 May;63(S1):1855-P. 

Thatcher M, Tippetts T, Johnson I, Holub Z, Nelson M, Winden DR, Reynolds PR, Bikman BT. Ceramide mediates cigarette smoke-induced skeletal muscle metabolic disruption. Diabetes. 2014 May;63(S1):1854-P. 

Nelson MB, Tippetts T, Winden DR, Reynolds PR, Bikman BT. RAGE activation reduces cardiomyocyte mitochondrial function in a ceramide-dependent manner. Diabetes. 2014 May;63(S1):447-P. 

Chavez CM, Mecham D, Wilhelm S, Black C, Mitchell J, Anderson K, Graf J, Macdonald J, Reynolds PR, Kooyman DL. Knocking out RAGE disrupts natural repair of condylar cartilage during osteoarthritis. FASEB J. 2014 Apr;28(1):835.14. 

Jimenez FR, Lewis JB, Belgique ST, Wood TT, Reynolds PR. Pulmonary expression and regulation of Cldn6 by tobacco smoke. FASEB J. 2014 Apr;28(1):834.3. 

Wood TT, Winden DR, Barton DB, Betteridge BC, Marlor DR, Wright AJ, Jones CM, Chavarria M, Rogers GD, Reynolds PR. Targeted mice reveal a role for RAGE in an early inflammatory response to tobacco smoke. FASEB J. 2014 Apr;28(1):834.4. 

Kooyman DL, Reynolds PR, Wilhelm SK, Mecham D, Chavez EM, Kartchner JZ, Crepeau P, Andersen K, Vandruff J, Robinson M, et al. Blocking the receptor for advanced glycation end-products but not Toll-like receptor 4 attenuates the progression of OA. FASEB J. 2014 Apr;28:835.13. 

Reynolds PR. Characterization of a new mouse model of COPD via conditional over-expression of RAGE by alveolar epithelium. Proc Phys Soc. 2013 Jul:PCD055. 

Jimenez FR, Lewis JB, Wood TT, Reynolds PR. Developmental expression and transcriptional regulation of claudin-6 in the murine lung. FASEB Journal. 2013 Apr;27:256.4. 

Bennion BG, Bodine BG, Leatham E, Wright AJ, Jergensen ZR, Erickson CJ, Jones CM, Johnson Jp, Knapp SM, Reynolds PR. Over-expression of RAGE by proximal lung epithelial cells causes an inflammatory response in adult mice. FASEB Journal. 2013 Apr;27:137.12. 

Barton DB, Betteridge BC, Earley TD, Robinson AB, Reynolds PR. RAGE signaling influences diesel particulate matter-induced inflammation in primary alveolar macrophages. FASEB Journal. 2013 Apr;27:254.11. 

Thatcher MO, Brassfield ES, Smith ME, Nelson MB, Reynolds PR, Bikman BT. Smoking mediates smoking-induced insulin resistance. FASEB Journal. 2013 Apr;27:874.27. 

Kooyman DL, Kartchner JZ, Peterson DM, Larkin DJ, Doxey AS, Hollis WR, Rees JL, Jackson GG, Wilhelm SK, Haynie SS, et al. The temporal expression of biomarkers associated with osteoarthritis after knee destabilizing surgery in mice with and without Receptor for Advanced Glycation End Products (RAGE). FASEB Journal. 2013 Apr:LB139. 

Wilhelm SK, Doxey AS, Kartchner JZ, Vandruff J, Andersen K, Draper CS, Chavez E, Reynolds PR, Kooyman DL. Apoptosis Associated with Osteoarthritis is Attenuated in Mice Lacking the Receptor for Advanced Glycation End Products (RAGE). FASEB Journal. 2013 Apr;27:573.5. 

Larkin DJ, Kartchner JZ, Doxey AS, Hollis WR, Rees JL, Wilhelm SK, Draper CS, Peterson DM, Jackson GC, Ingersoll C, et al. Inflammatory markers associated with osteoarthritis after destabilization surgery in mice with and without Receptor for Advanced Glycation End Products (RAGE). FASEB Journal. 2013 Apr;27:573.3. 

Curtis CS, Earley TD, Robinson AB, Reynolds PR. Diesel particulate matter (DPM) induces receptor for advanced glycation end-products (RAGE) expression by pulmonary macrophages. FASEB. 2012 Apr;26:143.1. 

Jacobs M, Hardman S, Moore T, Lewis J, Reynolds PR, Thomson DM. RAGE and STAT3 signaling in chronic AICAR-treated young adult and old skeletal muscle. The Physiologist. 2012 Apr;55(6):c-56. 

Johnson KD, Robinson AB, Reynolds PR. RAGE signaling influences smoke-induced secretion of pro-inflammatory cytokines by primary alveolar macrophages. FASEB. 2012 Apr;26:656.3. 

Robinson AB, Johnson KD, Bennion BG, Reynolds PR. RAGE signaling influences tobacco smoke-induced inflammation by pulmonary macrophages. FASEB. 2012 Apr;26:1064.10. 

Farmer AW, Reynolds PR. Receptors for advanced glycation end-products (RAGE) are transcriptionally inhibited by FoxA2 in diverse pulmonary cell types. FASEB. 2012 Apr;26:1151.13. 

Geyer AJ, Ferguson NT, Reynolds PR. Conditional embryonic over-expression of RAGE in the mouse lung diminishes pulmonary endothelium expression. Developmental Biology. 2011 Jul;356:356:A73, #121. 

Bukey BR, Porter JL, Hancock JM, Stogsdill JA, Reynolds PR. Increased MMP-9 activity in mice that over-express RAGE in alveolar epithelium destabilizes the basement membrane by degrading collagen type IV. Developmental Biology. 2011 Jul;356:356:A73, #122. 

Fredrickson AC, Sefcik TL, Reynolds PR. A new RAGE blocker, low anti-coagulant 2-O,3-O desulfated heparin (ODSH), diminishes smoke-induced pulmonary inflammation. FASEB J. 2011 Mar;25:25:114.5. 

Stogsdill JA, Stogsdill MP, Reynolds PR. Embryonic over-expression of RAGE in mouse lung causes an imbalance between apoptosis and proliferation leading to severe lung hypoplasia. FASEB J. 2011 Mar;25:25:660.6. 

Stogsdill MP, Stogsdill JA, Porter JL, Bodine BG, Reynolds PR. Persistent over-expression of RAGE in adult mouse lung causes airspace enlargement coincident with emphysema. FASEB J. 2011 Mar;25:25:114.6. 

Porter JL, Bukey BR, Geyer AJ, Reynolds PR. Temporal-Spatial Expression of α5 Nicotinic Acetylcholine Receptor (nAChR) Subunits During Mouse Lung Organogenesis. FASEB J. 2011 Mar;25:25:660.1. 

Stogsdill JA, Phinney MM, Reynolds PR. Conditional up-regulation of Receptors for Advanced Glycation End-Products (RAGE) in Alveolar Epithelium Causes Respiratory Distress and Perinatal Lethality. FASEB J. 2010 Apr:24:798:4. 

Willnauer CP, Reynolds PR. TTF-1 Transcriptionally Regulates α5 nAChRs in Subsets of Proximal and Distal Lung Epithelial Cells. FASEB J. 2010 Apr:24:798:1. 

Wasley KM, Allison CH, Reynolds PR. Diesel Particulate Matter Induces Receptor for Advanced Glycation End-Products (RAGE) Expression in Alveolar Epithelial Cells and Mediates an Inflammatory Respons. FASEB J. 2010 Mar:24:712:2025:114.5. 

Willnauer CP, Allison CH, Reynolds PR. TTF-1 and Egr-1 Differentially Regulate alpha 5 nAChRs in Proximal Lung Epithelium During Lung Development. Mech Dev. 2009 Sep;126:S214. 

Reynolds PR, Schmitt RE, Kasteler SD, Hoidal JR. The receptor for advanced glycation end products (RAGE) activates Ras and NFk-? in pulmonary epithelial cells exposed to cigarette smoke. PATS. 2009 May;179:A435. 

Kasteler SD, Reynolds PR, Hoidal JR. Downstream effects of receptors for advanced glycation end products (RAGE) in pulmonary epithelial cells exposed to cigarette smoke. Proceedings of the American Thoracic Society (PATS). 2008 Apr:177:A333. 

Reynolds PR, Kasteler SD, Sturrock A, Sanders K, Kennedy TP, Hoidal JR. RAGE targeting leads to protection from hyperoxia-induced lung injury. FASEB J. 2008 Apr;22:762.2. 

Reynolds PR, Hoidal JR. Expression and TTF-1-mediated Transcriptional Control of α5 nAChRs in the Developing Mouse Lung. Dev Biol. 2007 Sep:306:354. 

Reynolds PR, Kasteler SD, Hoidal JR. Cigarette smoke-mediated regulation of receptors for advanced glycation end products by Egr-1. Proceedings of the American Thoracic Society (PATS). 2007 Jun:175:A257. 

Presentations

Tippetts T, Winden DR, Wagner M, Condie T, Reynolds PR, Bikman BT. Ceramide is necessary for cigarette smoke-induced reduced heart mitochondrial function. American Diabetes Association. San Francisco, CA. 2014 . 

Thatcher M, Tippetts T, Johnson I, Holub Z, Nelson MB, Winden DR, Reynolds PR, Bikman BT. Pulmonary expression and regulation of Cldn6 by tobacco smoke. American Diabetes Association. San Francisco, CA. 2014 . 

Nelson MB, Tippetts T, Winden DR, Reynolds PR, Bikman BT. RAGE activation reduces cardiomyocyte mitochondrial function in a ceramide-dependent manner. American Diabetes Association. San Francisco, CA. 2014 . 

Wilhelm SK, Mecham D, Chavez EM, Kartchner JZ, Crepeau P, Andersen K, Vandruff J, Robinson M, Christensen I, Taylor K, et al. Blocking the receptor for advanced glycation end-products but not Toll-like receptor 4 attenuates the progression of OA. Federation of American Societies for Experimental Biology. San Diego, CA. 2014 . 

Chavez EM, Mecham D, Wilhelm SK, Black CS, Mitchell J, Andersen K, Graf J, Macdonald J, Reynolds PR, Kooyman DL. Knocking out RAGE disrupts natural repair of condylar cartilage during osteoarthritis. Federation of American Societies for Experimental Biology. San Diego, CA. 2014 . 

Jimenez FR, Lewis JB, Belgique ST, Wood TT, Marlor DR, Reynolds PR. Pulmonary expression and regulation of Cldn6 by tobacco smoke. Federation of American Societies for Experimental Biology. San Diego, CA. 2014 . 

Wood TT, Winden DR, Barton DB, Betteridge BC, Marlor DR, Wright AJ, Jones CM, Chavarria M, Rogers GD, Reynolds PR. Targeted mice reveal a role for RAGE in an early inflammatory response to tobacco smoke. Federation of American Societies for Experimental Biology. San Diego, CA. 2014 . 

Felix JR, Joshua LB, Tyler WT, Reynolds PR. Developmental expression and transcriptional regulation of claudin-6 in the murine lung. Experimental Biology Meeting. Boston, MA. 2013 . 

G BB, Garrett BB, Emma L, Alex WJ, Zac JR, COnnor EJ, Cameron JM, Jeffrey JP, Steve KM, Reynolds PR. Over-expression of RAGE by proximal lung epithelial cells causes an inflammatory response in adult mice. Experimental Biology Meeting. Boston, MA. 2013 . 

David BB, Bryce BC, Tyler ED, Adam RB, Reynolds PR. RAGE signaling influences diesel particulate matter-induced inflammation in primary alveolar macrophages. Experimental Biology Meeting. Boston, MA. 2013 . 

Jacobs MB, Hardman SE, Moore TM, Lew J, Reynolds PR, Thomson DM. RAGE and STAT3 signaling in chronic AICAR-treated young adult and old skeletal muscle. Integrative Biology of Exercise. Denver, CO. 2012 . 

Curtis CT, Earley TD, Reynolds PR. Diesel particulate matter (DPM) induces receptor for advanced glycation end-products (RAGE) expression by pulmonary macrophages. Experimental Biology Meeting. San Diego, CA. 2012 . 

Robinson AB, Reynolds PR. RAGE signaling influences tobacco smoke-induced inflammation by pulmonary macrophages. Experimental Biology Meeting. San Diego, CA. 2012 . 

Stogsdill JA, Reynolds PR. Embryonic over-expression of RAGE in mouse lung causes an imbalance between apoptosis and proliferation leading to severe lung hypoplasia. Gordon Research Conference: Lung development, injury, and repair. Newport, RI. 2011 . 

Reynolds PR. Abnormal RAGE expression influences lung development trajectory and disease progression. Pharmacy and Pharmaceutical Sciences Seminar. Dublin, Ireland. 2011 . 

Fredrickson AC, Sefcik T, Reynolds PR. A new RAGE blocker, low anti-coagulant 2-O,3-O desulfated heparin (ODSH), diminishes smoke-induced pulmonary inflammation. Experimental Biology Meeting. Washington, DC. 2011 . 

Stogsdill JA, Stogsdill MP, Reynolds PR. Embryonic over-expression of RAGE in mouse lung causes an imbalance between apoptosis and proliferation leading to severe lung hypoplasia. Experimental Biology Meeting. Washington, DC. 2011 .